经常使用的年长男人勃起功能障碍一项新研究表明，药物可能更有可能产生严重的副作用，从而导致视力丧失和失明。
Some isolated case reports and small studies have previously linked erectile dysfunction drugs to serious vision-related side effects. These include retinal detachment, when the retina lifts away from the back of the eye; retinal vascular occlusion, when clots block veins in the eye; and ischemic optic神经病, when blood stops flowing to the optic nerve. These conditions can come on suddenly, and lead to permanent vision loss if they aren’t treated quickly.
对于新研究，研究人员希望通过在平均四年的平均随访期内检查一群更大的男性来评估这些较小的研究中看到的风险。他们分析了有关213,000多名男性的健康保险索赔数据，这些男性在一个被称为磷酸二酯酶5型抑制剂（PDE5IS）的药物家庭中收到了四种勃起功能障碍药物之一的新处方：西地那非（伟哥），tadalafil（cialis），瓦丁纳非（Levitra，Staxyn）和Avanafil（Stendra）。该分析比较了使用这些药物的男性与没有的男性的眼镜相关副作用。
Overall, men who regularly used erectile dysfunction drugs were 85 percent more likely to develop serious vision-related side effects than men who didn’t take these medicines, researchers report inJAMA眼科。
当研究人员孤立地看每种类型的眼副作用时，他们发现定期勃起功能障碍药物使用与严重视网膜脱离的风险高2.8倍，缺血性视神经神经病的风险加倍，并增加了44％的视网膜血管咬合风险。
“The findings suggest individuals who regularly use PDE5Is need to be cognizant of ocular adverse events associated with these drugs and alert their physicians if they experience any visual deficits,” the researchers concluded.
研究人员将常规勃起功能障碍药物使用定义为每三个月至少填充一份处方。该研究的一个局限性是，这只会告诉研究人员，男人多久拿起一瓶药丸，而不是男人实际使用这些药丸的频率。
该研究还不是一个受控的实验，旨在证明勃起功能障碍药物是否可能直接引起与眼睛有关的副作用。
但是，有一些可行的解释，说明为什么这些药物会引起这些副作用，医学博士Brian Vanderbeek，MD，MPH和Maureen Maguire博士，宾夕法尼亚大学的宾夕法尼亚大学宾夕法尼亚大学的博士学位。社论随附研究。
For example, ischemic optic neuropathy can develop in people who have unusually low blood pressure at night, the editorial authors write. Erectile dysfunction drugs are often used at night, and are known to lower blood pressure, they note.
In addition, erectile dysfunction drugs can cause thickening of tissue in the middle layer of the wall of the eye, a condition that is associated with retinal detachment, the editorial authors point out. The possible mechanisms for these drugs to cause retinal vascular occlusion aren’t as clear, they write, but it’s possible these medicines might have a negative effect on blood flow within the eyes.
